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Two-Layer Appearance on Brain Perfusion SPECT in Idiopathic Normal Pressure Hydrocephalus: A Qualitative Analysis by Using Easy Z-Score Imaging System, eZIS
Dementia and Geriatric Cognitive Disorders, 10/26/09

Kobayashi S et al. – Hypoperfusion around the corpus callosum in iNPH could be, at least partially, a false–positive finding due to an insufficient anatomical standardization of SPECT images caused by an abnormally enlarged ventricle. Increased blood perfusion in the external layer adjacent to the hypoperfused area might be caused by increased radioisotope count per volume resulting from exclusion of cerebral cortex by a dilated ventricle. These results demonstrate that a two–layer appearance revealed by the two–tailed view analysis of brain perfusion SPECT using eZIS could be a means to detect iNPH.

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