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Gene expression changes in blood as a putative biomarker for Huntington's disease
Movement Disorders, 10/26/09

Lovrecic L et al. – The aim of this study was to validate expression changes of these 12 genes in an independent cohort of HD patients and evaluate their sensitivity and specificity. Four different subject groups were included – patients with HD, Parkinson's disease (PD), acute ischemic stroke (AS) and healthy controls. Although the previous results were successfully validated, gene expression changes in HD blood partly overlapped with those observed in blood from PD and AS patients. Predictive value of the selected biomarker set for HD group was 78%, with 82% sensitivity and 53% specificity. Further gene expression analyses in longitudinal studies are needed to validate and refine possible transcriptomic blood biomarkers in HD.

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Lundbeck receives important award in the USA for its effort against Huntington's disease
Lundbeck, 10/13/09 Relevance Score: 69%

The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases
CNS Neuroscience & Therapeutics, 11/11/09 Relevance Score: 68%

Growth hormone and ghrelin secretion are associated with clinical severity in Huntington's disease
European Journal of Neurology, 11/04/09 Relevance Score: 67%

Early Testing for Huntington Disease in Children: Pros and Cons
Journal of Child Neurology, 10/16/09 Relevance Score: 67%

FUS-Immunoreactive Intranuclear Inclusions in Neurodegenerative Disease
Brain Pathology, 10/16/09 Relevance Score: 67%