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Free insulin-like growth factor (IGF)-1 and IGF-binding proteins-2 and -3 in serum and cerebrospinal fluid of amyotrophic lateral sclerosis patients
European Journal of Neurology, 11/05/09

Corbo M et al. – Though in the serum the authors did not find significant differences amongst the three groups, IGF–1 bioavailability, represented by the free IGF–1 levels, correlated with disease severity. In the CSF, the significant increment of the free fraction of IGF–1 suggests an up–regulation of the IGF–1 system in the intrathecal compartment of sALS patients. Since IGF–1 is a trophic factor for different tissues, they speculate that high levels of the free IGF–1 in sALS might reflect a physiological defensive mechanism promoted in response to neural degeneration and/or muscle atrophy.

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