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See Latest ArticlesBrainstem disconnection associated with nodular heterotopia and proatlantal arteries
American Journal of Medical Genetics, 10/23/09
Okumura A et al. – MR angiography demonstrated the absence of vertebral arteries and presence of bilateral proatlantal intersegmental arteries arising from the external carotid arteries. Array–comparative genomic hybridization analysis did not show any genomic copy number aberrations. No mutation was found in the FLNA gene or the EN2 gene. The constellation of the malformations of their patient suggested that genes related to the development of the central nervous and vascular system may be involved in the pathogenesis of brainstem disconnection.
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