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Valproic acid-induced encephalopathy in very long course treated patients
Brain Injury, 10/22/09
Rousseau MC et al. – This study confirms that, under VPA treatment, hyperammonaemia is a current event; 25.4% patients presented isolated elevated ammonaemia when receiving VPA for very long durations. VPA therapy should be monitored closely and clinicians must be warned of VPA encephalopathy signs.
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