Neurology Medical News about Pain Haplotypes GCH1

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Cross-sectional Assessment of the Consequences of a GTP Cyclohydrolase 1 Haplotype for Specialized Tertiary Outpatient Pain Care
The Clinical Journal of Pain, 10/21/09

Doehring A et al. – The results strength the support for a modest yet reproducible and consistent pain–protective effect associated with a GCH1 haplotype known to reduce GCH1 and thus BH4 up–regulation. Pending independent verification, the results might point to a prophylactic role of decreased GCH1 up–regulation delaying the need for pain therapy.

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