Neurology Medical News about Hyperhidrosis Pain Insensitivity, Congenital

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Absence of pain with hyperhidrosis: A new syndrome where vascular afferents may mediate cutaneous sensation
Pain, 10/19/09

Bowsher D et al. – Congenital absence of pain perception is a rare phenotype. Here the authors report two unrelated adult individuals who have a previously unreported neuropathy consisting of congenital absence of pain with hyperhidrosis (CAPH)...These findings suggest three hypotheses: (1) that development or maintenance of sensory innervation to cutaneous vasculature and sweat glands may be under separate genetic control from that of all other cutaneous sensory innervation, (2) the latter innervation is preferentially vulnerable to some environmental factor, and (3) vascular and sweat gland afferents may contribute to conscious cutaneous perception.

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