Neurology Medical News about Pain Satellite Cells, Perineuronal

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Gliopathic Pain: When Satellite Glial Cells Go Bad
The Neuroscientist, 10/16/09

Ohara PT et al. – Neurons in sensory ganglia are surrounded by satellite glial cells (SGCs) that perform similar functions to the glia found in the CNS. When primary sensory neurons are injured, the surrounding SGCs undergo characteristic changes. There is good evidence that the SGCs are not just bystanders to the injury but play an active role in the initiation and maintenance of neuronal changes that underlie neuropathic pain. In this article the authors review the literature on the relationship between SGCs and nociception and present evidence that changes in SGC potassium ion buffering capacity and glutamate recycling can lead to neuropathic pain–like behavior in animal models. The role that SGCs play in the immune responses to injury is also considered. The authors propose the term gliopathic pain to describe those conditions in which central or peripheral glia are thought to be the principal generators of principal pain generators.

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Dissecting the functional significance of endothelin A receptors in peripheral nociceptors in vivo via conditional gene deletion
Pain, 11/02/09 Relevance Score: 68%

T-Cell Recognition of Prostatic Peptides in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome
The Journal of Urology, 10/14/09 Relevance Score: 68%

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Current Challenges in Glia-Pain Biology
Neuron, 10/22/09 Relevance Score: 67%

Satellite tumors surrounding primary pleomorphic adenomas of the parotid gland
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