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A phenotypically restricted set of primary afferent nerve fibers innervate the bone versus skin: Therapeutic opportunity for treating skeletal pain
Bone , 10/16/09

Jimenez–Andrade JM et al. – Although musculoskeletal pain is one of the most common causes of chronic pain and physical disability in both developing and developed countries, relatively little is known about the nerve fibers and mechanisms that drive skeletal pain. Small diameter sensory nerve fibers, most of which are C–fiber nociceptors, can be separated into two broad populations: the peptide–rich and peptide–poor nerve fibers...Therapies that target the specific types of C–nerve fibers that innervate the bone may be uniquely effective in attenuating skeletal pain as compared to skin pain.

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