Neurology Medical News about Capsaicin Pain Models, Neurological

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A comparison of two formulations of intradermal capsaicin as models of neuropathic pain in healthy volunteers
British Journal of Clinical Pharmacology, 10/16/09

Gustafsson H et al. – Intradermal capsaicin has some utility as a model of neuropathic pain. Dose–response relationships have not been well documented. Two formulations have previously been used but their performance has not been compared...The formulations are comparable over the dose range 1–30 microg. The significantly lower pain response at the 100 microg dose in the Tween compared with the HP–?–CD formulation is likely to be due to limitations in solubility at the 100 microg level. Given the greater ease of formulation and the superior dose–response relationship, the HP–?–CD formulation is preferable for use in the model in future studies.

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