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Blood Pressure and Stroke in Heart Failure in the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Stroke, 10/19/09
Pullicino PM et al. – The odds of prevalent self–reported stroke/TIA are increased in participants with HF and most markedly increased in participants with low SBP. Longitudinal data are needed to determine whether this reflects stroke/TIA secondary to thromboembolism from poor cardiac function or secondary to cerebral hypoperfusion.
Patrick M. Pullicino, 10/20/09
| There has long been a concern that there is a subgroup of patients in whom excessive lowering of blood pressure may be a risk for stroke. I think that what these data are telling us is that stroke risk increases when systolic blood pressure falls because of advanced heart failure and not that hypertension should not be treated in heart failure. These findings need confirmation and further research is needed to determine if heart failure patients with low systolic blood pressure would benefit from anticoagulation. A fuller discussion of stroke in heart failure will be published as an editorial in Journal of Stroke and Cerebrovascular Diseases in January 2010. |
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