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Revision of the risk of secondary leukemia after mitoxantrone in multiple sclerosis populations is required
Multiple Sclerosis, 10/26/09
Pascual AM et al. – The real incidence of acute myeloid leukaemia after mitoxantrone therapy in the multiple sclerosis population could be higher as evidenced by the growing number of cases reported. Haematological monitoring should continue for at least 5 years after the last dose of mitoxantrone. These data stress the necessity of re–evaluating this risk.
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Effect of IFN-beta therapy on the frequency and function of CD4+CD25+ regulatory T cells and Foxp3 gene expression in relapsing–remitting multiple sclerosis (RRMS): A preliminary study
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