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Corticosteroids (dexamethasone versus intravenous methylprednisolone) in patients with tuberculous meningitis
Annals of Tropical Medicine and Parasitology, 10/15/09
Malhotra HS et al. – In an open–label study in India, 97 patients with such meningitis were randomized into a control group, a dexamethasone group (with the drug given intravenously once a day for 4 weeks, and then orally, once daily, for another 4 weeks) and a methylprednisolone group (with the drug given intravenously once a day for 5 days). Adverse events were similar and equally reported in the two corticosteroid groups. Larger trials are still needed to determine if dexamethasone and/or methylprednisolone are useful in the treatment of tuberculous meningitis, at least in India.
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