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Stress-opioid interactions: a comparison of morphine and methadone
Pharmacological Reports, 10/12/09

Taracha E et al. – Methadone had greater cataleptogenic and analgesic potency than morphine. Fos immunohistochemistry revealed substantial effects on the Fos response of both the stress induced by the experimental procedures and of the drug exposure itself. There were three response patterns identified: 1) drug exposure, but not stress, significantly elevated Fos–positive cell counts in the caudate–putamen; 2) stress alone and stress combined with drug exposure similarly elevated Fos–positive cell counts in the nucleus accumbens and cingulate cortex; and 3) methadone and morphine (to a lesser extent) counteracted the stimulatory effect of nonpharmacological stressors on Fos protein expression in the somatosensory cortex barrel field, and Fos–positive cell counts in this region correlated negatively with both the duration of catalepsy and the latency time in the hot–plate test. The overlap between brain regions reacting to nonpharmacological stressors and those responding to exogenous opioids suggests that stress contributes to opioid–induced neuronal activation.

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