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Wilke C et al. – Although localization of neocortical–onset seizures is typically challenging, the causal measures employed in this study—namely the directed transfer function—identified generators of the ictal activity that were highly correlated with the cortical regions identified as the seizure–onset zones by the epileptologists. This technique could prove useful in the identification of seizure–specific propagation pathways in the presurgical evaluation of patients with epilepsy.


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