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Klein O et al. – The study stresses the important inter and intra–subject variability of Q'extcsf in patients with EVD. The mean Q'extcsf is lower than the reference production rate (21 ml/h), raising the question of persistent CSF absorption and/or depressed secretion. The independent changes of Q'extcsf and ICP on the short term is likely to be explained by the pressure–volume characteristics of the intracranial space.

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