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See Latest ArticlesLong-term follow-up of the original interferon-beta1b trial in multiple sclerosis: Design and lessons from a 16-year observational study
Clinical Therapeutics, 10/16/09
Ebers GC et al. – Although most patients (88.2%) were identified at long–term follow–up (LTF), ascertainment was incomplete. This was attributable to patients' refusal to participate, loss to follow–up, or death. Delays in the registration of death data and recent privacy legislation provided further barriers. Mortality was lower for patients originally randomized to receive IFN–beta1b rather than placebo. The authors recommend that all short–term trials on chronic diseases include provisions for LTF.
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