Neurology Medical News about Aged Neuralgia, Postherpetic Herpes Zoster

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McKendrick MW et al. – Long term pain in the elderly following zoster is associated with identifiable characteristics during the acute illness.

Methods

Late follow up of patients originally admitted with acute zoster to a double blind randomised placebo controlled study of oral acyclovir over 60years of age.

Results

158 of the 298 patients from the original study were available for evaluation at a mean follow up of 9years.
Thirty four (21%) described experiencing pain from the zoster within the previous 12 months.
Pain at follow up was associated with characteristics at the time of acute zoster of: moderate or severe acute pain, prodromal pain >72h before rash, severity of rash and female gender.
There was no association between pain at 9 year follow up and use of placebo or aciclovir nor with the presence or absence of pain at the point of discharge from the original study.
Further analysis of 17 of the 34 patients with long term pain who have full data available, the median pain score was 4 out of 10 and more than 50% described persistent pain and interference with sleep.

Postherpetic Neuralgia: From Preclinical Models to the Clinic
Neurotherapeutics, 10/05/09 Relevance Score: 89%

Treatment of Herpes Zoster and Postherpetic Neuralgia
Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 10/19/09 Relevance Score: 88%