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White matter abnormalities and dystonic motor disorder associated with mutations in the SLC16A2 gene
Developmental Medicine & Child Neurology, 10/27/09

Gika AD et al. – The findings indicate a consistent association between defective neuronal T3 uptake and delayed myelination. SLC16A2 involvement should be considered in males with learning disability, an associated motor or movement disorder, and evidence of delayed myelination on brain MRI. Although dysmorphic features suggestive of AHDS are not always present, T3 measurement is a reliable screening test.

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