Neurology Medical News about Medulloblastoma

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A novel role of cyclinD1 and p16 in clinical pathology and prognosis of childhood medulloblastoma
Medical Oncology, 10/09/09

Zhao X et al. – The authors found a statistically significant relationship between the percent of cyclinD1–positive cells and p16–positive cells in the tumors and clinical outcome, with higher levels of cyclinD1 and lower levels of p16 correlating with a worse prognosis. CyclinD1 and p16 may be independent biomarkers for clinical prognosis in MB. A combined detection of cyclinD1+/p16? expression may benefit us in prediction of a poor survival of MB.

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Incomplete Penetrance of the Predisposition to Medulloblastoma Associated With Germ-Line Sufu Mutations
Journal of Medical Genetics, 10/29/09 Relevance Score: 88%

Analysis of microsatellite instability in medulloblastoma
Neuro-Oncology, 10/07/09 Relevance Score: 88%

The Alkylphospholipid Perifosine Induces Apoptosis and p21-Mediated Cell Cycle Arrest in Medulloblastoma
Molecular Cancer Research, 11/06/09 Relevance Score: 83%

Medulloblastoma in childhood: revisiting intrathecal therapy in infants and children
Cancer Chemotherapy and Pharmacology, 10/29/09 Relevance Score: 82%

Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumors
Journal of Neuro-Oncology, 10/01/09 Relevance Score: 82%