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Bencherif M et al. – The convergence of beta–amyloid deposition and/or ApoE4 binding and co–localization with alpha7 NNRs, which are favored under conditions of low cholinergic tone, and the downstream cascade of tau hyperphosphorylation through disinhibition of GSK–3beta appear to explain and reconcile many of the discordant findings in this very active area of CNS research.

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