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"Cloud-like enhancement" is a magnetic resonance imaging abnormality specific to neuromyelitis optica
Annals of Neurology , 10/08/09

Ito S et al. – Brain MRI abnormalities were found for 89% of the patients, and the most prominent feature was "Cloud–like enhancement", multiple patchy enhancing lesions with blurred margin, found in 90% of the patients with positive contrast enhancement. In NMO, brain MRI abnormalities are frequent, and cloud–like enhancement appears to be an MRI finding specific to NMO, possibly caused by primary involvement of the blood–brain barrier by the autoantibodies.

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