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See Latest ArticlesMatrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
European Journal of Neurology, 10/12/09
Niebroj–Dobosz I et al. – Increased level of MMPs and TIMP–1 of ALS patients may reflect the degeneration process of motor neurons and skeletal muscles and/or is associated with tissues remodeling. The low level of MMP–9 in CSF may result from impaired balance between MMP–9 and TIMP–1 and/or its increased intrathecal degradation and physical clearance. Although the role of changed MMPs/TIMPs level in the pathogenesis of ALS is not clear their analysis in serum may be used as prognostic factor and a potential marker for monitoring treatment effects.
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HLA-DRB1 allele heterogeneity influences multiple sclerosis severity as well as risk in Western Australia
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