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Reduced limbic connections may contraindicate subgenual cingulate deep brain stimulation for intractable depression
Journal of Neurosurgery, 10/06/09
McNab JA et al. – In this study, the authors performed deep brain stimulation (DBS) of the subgenual anterior cingulate cortex (SACC) in a patient with a history of bipolar disorder. After a right thalamic stroke, intractable depression without mood elevation or a mixed state developed in this patient. He underwent bilateral SACC DBS and died 16 months afterwards.
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