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See Latest ArticlesDistinct striatal targets in treating obsessive-compulsive disorder and major depression
Journal of Neurosurgery, 10/06/09
Aouizerate B et al. – The findings suggest that the caudate nucleus and nucleus accumbens participate differently in the pathogenesis of both of these psychiatric conditions.
Bruno Aouizerate, 10/07/09
| Deep Brain Stimulation (DBS) has recently been proposed for the management of severely incapacitating and resistant forms of psychiatric diseases especially including obsessive-compulsive disorder (OCD) and major depression. By targeting the ventral striatum, DBS has been shown to be of special benefit for these patients, who failed to be sufficiently improved with combined pharmacological and psychological treatments. By developing a relevant 3D human atlas and establishing reliable anatomical-clinical correlations, DBS also offers the opportunity to improve current knowledge of the role of basal ganglia in the pathophysiology of OCD and major depression and to identify functional subterritories within the ventral striatum, which are specifically involved in the production of clinical symptoms. |
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