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Velasco F et al. – Motor cortex stimulation (MCS) is effective not only to treat pain, but also improve the sympathetic changes in CPRS. Mechanism of action is actually unclear, but seems to involve sensory input at the level of the spinal cord.

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Francisco Velasco, 10/06/09

CPRS involving large corporal segments or the entire hemibody may be treated by cortical stimulation of an area not larger of 4 cm2. Although analgesic effect of MCS seems to involve sensory input at the level of the dorsal horn of spinal cord, clinical results in patients with complete motor and sensory deafferentation of painful area, indicates that they must be some other mechanism involved in analgesia. It is possible that improvement in sympathetic symptoms have also effect on severity of neuropathic pain.

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