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Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma
Neurology, 10/13/09
Yu J et al. – BRAF rearrangement represents the most common genetic alteration in sporadic, but not neurofibromatosis type 1–associated, pilocytic astrocytomas (PAs). These findings implicate BRAF in the pathogenesis of these common low–grade astrocytomas in children, and suggest that PAs arise either from NF1 inactivation or BRAF gain of function.
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