Neurology Medical News about Neurotransmitter Agents Pain Nitric Oxide

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Involvement of S-nitrosylation of actin in inhibition of neurotransmitter release by nitric oxide
Molecular Pain, 10/01/09

Lu J et al. – The role of the diffusible messenger nitric oxide (NO) in the regulation of pain transmission is still a debate of matter, pro–nociceptive and/or anti–nociceptive. S–Nitrosylation, the reversible post–translational modification of selective cysteine residues in proteins, has emerged as an important mechanism by which NO acts as a signaling molecule. The occurrence of S–nitrosylation in the spinal cord and its targets that may modulate pain transmission remain unclarified...The present study demonstrates that actin is a major S–nitrosylated protein in the spinal cord and suggests that NO directly regulates neurotransmitter release by S–nitrosylation in addition to the well–known phosphorylation by cGMP–dependent protein kinase.

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