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Hippocampal dysfunction in amnestic-type mild cognitive impairment: implications for predicting Alzheimer’s risk
Future Neurology, 09/30/09

Bai F et al. – Since hippocampal dysfunction has been widely reported in patients with amnestic–type mild cognitive impairment (MCI) with Alzheimer’s risk, a number of studies have focused on this region of the brain; these studies are reviewed here. Three principle findings are highlighted: first, impaired hippocampal function relates to disturbances in episodic memory encoding and retrieval in MCI, but possibly in different ways; second, there is evidence of a nonlinear relationship between memory function and hippocampal activity as one progresses through the stages of MCI to Alzheimer’s disease; and third, hippocampal function is intimately related to default mode network mechanisms.

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