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Targeting Voltage-Gated Calcium Channels for Neuropathic Pain Management
Neurotherapeutics, 10/05/09

Perret D et al. – In this review, the authors summarized the most recent preclinical and clinical studies related to chronic pain medications acting on the VGCC. The authors also included clinical trials aiming to expand the application of approved VGCC drugs to different pain states derived from various pathological conditions, as well as drug combination therapies trying to improve the efficacies and side–effect profiles of current pain medications.

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CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels
Molecular Pharmacology, 11/10/09 Relevance Score: 67%

CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels
Molecular Pharmacology, 11/02/09 Relevance Score: 67%

Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway
Molecular Pharmacology, 11/02/09 Relevance Score: 66%

Results of a meta-analysis comparing the tolerability of lercanidipine and other dihydropyridine calcium channel blockers
Clinical Therapeutics, 10/15/09 Relevance Score: 66%

Protein kinase C-mediated inhibition of recombinant T-type Ca V 3.2 channels by neurokinin 1 receptors
Molecular Pharmacology, 10/13/09 Relevance Score: 66%