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What Is the Evidence for Chronic Pain Being Etiologically Associated with the DSM-IV Category of Sleep Disorder Due to a General Medical Condition? A Structured Evidence-Based Review
Pain Medicine, 09/28/09
Fishbain DA et al. – The results of this evidence–based structured review indicate that for the pain–sleep studies defined by the DSM–IV category of sleep disorder due to a general medical condition,chronic pain may be etiologically related to that sleep problem. However, these results do not preclude this relationship from being bidirectional.
Methods- Computer and manual literature searches yielded 146 references that addressed this area of study.
- 41 studies were reviewed in detail and sorted according to six natural groupings: multivariate analysis, prospective studies, path analysis, correlation between pain and sleep problems, univariate analysis using comparison groups, and do nonsedating drugs with analgesic properties improve sleep.
- Each study was independently evaluated by two raters according to 12 quality criteria and an independent quality score was calculated.
- For each of the above groupings, an average quality score was calculated and a calculation performed as to the percentage of studies that supported the hypothesis that pain is etiologically related to the above DSM–IV category of sleep disorders.
- Finally, the strength and consistency of the evidence for this hypothesis was rated according to the AHCPR guidelines.
- Of the 41 reports, all had quality scores greater than 60%.
- In all the above groupings except for multivariate analysis, 100% of the studies supported this hypothesis.
- In the multivariate analysis grouping, 77.2% of the studies supported this hypothesis.
- The strength and consistency of this evidence was rated at A (highest possible) for all study groupings except multivariate (B rating) and path analysis where there were too few studies to generate a conclusion.
- For all the studies combined, 89.7% of the studies supported this hypothesis. This evidence was rated as A: consistent, multiple studies.
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