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Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors
Expert Review of Neurotherapeutics, 10/08/09

Fournier A et al. – Independently of their preventive impact on beta–amyloid degenerative neuropathological process by overexpressing insulin degrading enzyme which catabolyses amyloid, the angiotensin AT1–receptor–blockers may have greater cognition protective effects than ACEI (observed in the ONTARGET trial), as they share with ACEI cognition–enhancing effects directly linked with a common AT1–blunting effect. In addition, they increase angiotensin II and IV formation and therefore stimulate non–opposed AT2 and AT4 receptors, whose activation in cognitive processes is well established.

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