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Angiotensin AT1-receptor blockers and cerebrovascular protection: do they actually have a cutting edge over angiotensin-converting enzyme inhibitors
Expert Review of Neurotherapeutics, 10/06/09
Oprisiu–Fournier R et al. – A careful analysis of the PRoFESS trial, however, reveals study design limitations, the main one being that diastolic BP (<80 mmHg) in the first month post–stroke may have been too low in at least one third of the population with baseline systolic blood pressure less than 130 mmHg, because a high dose of telmisartan was given after a very short post–stroke delay (median 15 days) without discontinuation of the baseline antihypertensive treatment.
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