Neurology Medical News about Baroreflex Cardiac Electrophysiology Pain Measurement

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Effects of unpredictable stimulation on pain and nociception across the cardiac cycle
Pain, 09/23/09

Martins AQ et al. – Under painful stimulation, intensity and unpleasantness varied in a quadratic manner across the cardiac cycle; pain was highest at R + 300ms and lowest at R + 0 and R + 600ms. Under non–painful stimulation, ratings declined linearly as the cycle progressed. Finally, nociceptive responses did not differ among the R–wave to stimulation intervals for both painful and non–painful intensities. The observed phasic modulation of pain may be explained by a central nervous system alarm/defence reaction triggered by the unpredictability of the potentially damaging stimulation. The absence of systolic attenuation of nociceptive responding is compatible with previous evidence that baroreceptor modulation of the NFR is abolished under conditions of heightened arousal.

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