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de Tommaso M et al. – Migraine patients exhibited increased laser evoked potentials (LEPs) amplitude and reduced habituation compared to normal subjects. Laser–pain perception was increased during the pre–menstrual phase in both patients and controls. Migraine patients and controls showed increased P2 and N2–P2 amplitude in the pre–menstrual phase, on both stimulation sites. During the pre–menstrual phase the N2–P2 habituation appeared to be reduced in both migraine and healthy women. The estrogen withdrawal occurring during the menstrual cycle may favor reduced habituation of nociceptive cortex, which may facilitate pain symptoms and migraine in predisposed women.

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