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See Latest ArticlesCholinergic switch associated with morphological differentiation in neuroblastoma
The Journal of Pathology, 09/22/09
Bourdeaut F et al. – Depending upon their association with adrenergic characteristics, this enables dual cholinergic/adrenergic and fully cholinergic neuroblastomas to be defined. This suggests that the cholinergic switch, a final specification process that occurs physiologically in a minority of sympathetic neurons, is a critical step of differentiation in some neuroblastic tumours. This switch is associated with a down regulation of DBH that is apparently not strictly dependent upon PHOX2B. Conversely, GATA2 and TFAP2B may play critical roles in maintaining adrenergic features in poorly differentiated tumours.
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