Neurology Medical News about Neuroectodermal Tumors, Primitive Neuroepithelial Cells

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Comparative analysis of annexin-1 in neuroepithelial tumors shows altered expression with the grade of malignancy but is not associated with survival
Modern Pathology, 09/22/09

Schittenhelm J et al. – Annexin-1 upregulation in astrocytomas may contribute to tumor progression and its expression profile is similar to its substrate, EGFR, suggesting a possible regulation thereof.

Methods

Annexin-1 expression was studied in 394 glial neoplasms of all grades of malignancy and 81 normal brain samples by immunohistochemistry using tissue microarrays
The results were validated using western blot and reverse transcription-PCR (RT-PCR)

Results

Ependymomas and astrocytomas showed significantly higher mean annexin-1 expression levels in the cytoplasm compared with oligodendrogliomas
In addition, nuclear staining of annexin-1 in oligodendroglial tumor cells was significantly reduced, which may be used as a diagnostic tool for differentiating between astrocytomas and oligodendrogliomas
Although annexin-1 expression in ependymomas decreased with the grade of malignancy, diffuse astrocytomas showed a significant increase in cytoplasmic annexin-1-positive tumor cells; however, survival analysis showed that the expression of annexin-1 is not associated with patient survival
Similar to the EGFR amplification profile, primary glioblastomas had a higher annexin-1 expression level compared with secondary glioblastomas

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