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Talaei A et al. – One hundred patients (50 in each group) completed the study. After treatment, the pain score based on a visual analogue scale decreased 3.66 units in the vitamin B12 group and 0.84 units in the nortriptyline group. Similarly, the paresthesia score decreased 2.98 units versus 1.06 units. The decrements of tingling sensation were 3.48 units versus 1.02 units. Changes in vibration, position, pinprick and nerve conduction parameters were not significant in two groups. In conclusion, vitamin B12 is more effective than nortriptyline for the treatment of symptomatic painful diabetic neuropathy.


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