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Pharmacogenetics and Stroke
Stroke, 10/05/09

Meschia JF – Genetic variations have been shown to influence drug metabolism, risk of adverse drug events, and pharmacodynamic responses for many drugs routinely used to treat patients with stroke or at risk for stroke. Examples include clopidogrel, statins, antihypertensive medications, and coumadin. Further validation studies are needed to assess the clinical utility of selecting drugs and doses based on genetic tests. Physicians, pharmaceutical companies, regulatory agencies, and health insurers continue to grapple with how best to translate this burgeoning field into effective individualized medicine.

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Differences Between Ischemic Stroke Subtypes in Vascular Outcomes Support a Distinct Lacunar Ischemic Stroke Arteriopathy. A Prospective, Hospital-Based Study
Stroke, 11/09/09 Relevance Score: 93%

Oral anticoagulant therapy safely prevented stroke in older patients with atrial fibrillation
Evidence-Based Medicine, 10/26/09 Relevance Score: 93%

Ischemic stroke and hyperhomocysteinemia: truth or myth
Acta Neurologica Belgica, 10/21/09 Relevance Score: 93%

Advancing the hypothesis that geographic variations in risk factors contribute relatively little to observed geographic variations in heart disease and stroke mortality
Preventive Medicine, 10/16/09 Relevance Score: 93%

Prevention and management of stroke in very elderly patients
The Lancet Neurology, 10/15/09 Relevance Score: 93%