Neurology Medical News about Pain Ganglia, Sensory

Become a Member Today!
Register

Most Viewed Abstracts

1. Report Shows Shift in Starting Salaries for Physicians

2. 2008 Exclusive Survey—Earnings: Good news for primary care income

3. Medicare pay-for-reporting effort draws fire from frustrated doctors

4. Debunking Myths in the US Healthcare System

5. Doctors and the DEA Free full text

Your Article Summary

See Latest Articles

(Click the title below to leave the MDLinx Network and go to the Journal's Website)

Contribution of the activation of satellite glia in sensory ganglia to pathological pain
Neuroscience & Biobehavioral Reviews, 09/17/09

Takeda M et al. – Although there are increasing reports that glia in the spinal cord contribute to the maintenance of pathological pain, recent evidence suggests that activation of satellite glia in sensory ganglia may also play an important role in the development of hyperalgesia and allodynia. There is evidence that non–synaptically released chemical mediators derived from both neurons and satellite glia may trigger chronic pain via autocrine and/or paracrine mechanisms and that augmented excitability of primary afferent neurons results in changes in central pain–signaling neurons (central sensitization). The focus of the present review is on the contribution of the activation of satellite glia in sensory ganglia to pathological pain. In addition, the authors discuss potential therapeutic targets in satellite glia – neuronal interactions for the prevention of pathological pain.

<< Previous
Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor...

Next >>
HTR2A gene variation is involved in antidepressant treatment...