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Management of myasthenic conditions: nonimmune issues
Current Opinion in Neurology, 09/28/09
Argov Z – Antisense compound inhibiting acetylcholine esterase has positive therapeutic effects during short–term administration, but further studies are needed to confirm its chronic effects. Pyridostigmine seems not to have an additional effect to 3–4 diaminopyridine in Lambert Eaton myasthenic syndrome. Bilevel positive airway pressure and other external respiratory supportive systems may prevent in some myasthenic crises the need for intubation or at least shorten it. Statins can aggravate myasthenia gravis but the risk is not well quantified, and these compounds are not completely contraindicated in myasthenia.
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