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Carrier J et al. – The combined influence of age and caffeine made the sleep of middle–aged subjects particularly vulnerable to the circadian waking signal. The authors propose that lower brain synchronization due to age and caffeine produces greater difficulty in overriding the circadian waking signal during daytime sleep and leads to fragmented sleep. These results have implications for the high proportion of the population using caffeine to cope with night work and jet lag, particularly the middle–aged.

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