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See Latest ArticlesProtein kinase Cgamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin
Human Molecular Genetics, 09/14/09
Asai H et al. – The phosphorylated residue was Thr111, located adjacent to the nuclear localization signal, and disturbed interactions with importin , a nuclear import adaptor. Decreased nuclear APTX increased oxidative stress–induced DNA damage and cell death. Phosphorylation–resistant APTX, kinase inhibitors, and antioxidants may be therapeutic options for SCA14.
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Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis
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Today in Movement Disorders...keeping you current
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Olfactory testing combined with dopamine transporter imaging as a method to detect prodromal Parkinsons disease.
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Depression in Parkinson's Disease
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