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The combinations of TNF-alpha–308 and IL-6 –174 or IL-10 –1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer's disease
Acta Neurologica Scandinavica, 09/17/09
Vural P et al. – The results suggest that TNF–alpha and IL–10 promoter polymorphism might be a risk factor for AD. The combined effects of TNF–alpha–308, IL–6 –174 and IL–10 –1082 variant alleles may be more decisive to induce functional differences and modify the risk for AD.
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