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Nitroglycerin provocation in normal subjects is not a useful human migraine model?
Cephalalgia, 09/15/09
Tvedskov JF et al. – This experiment suggests that headache caused by direct nitric oxide (NO) action in the continued presence of NO is very resistance to analgesics and to specific acute migraine treatments. This suggests that NO works very deep in the cascade of events associated with vascular headache, whereas tested drugs work higher in the cascade. The model suggested here should therefore be tested with other headache/migraine–provoking agents that supposedly work higher in the cascade of events. The need for human models persists, but the solution to this problem is still pending.
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