Neurology Medical News about epileptic neocortex;interictal high frequency oscillations

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Spatial characterization of interictal high frequency oscillations in epileptic neocortex
Brain, 09/14/09

Schevon CA et al. – The authors propose that large–scale HFOs, rather than the more frequent highly focal events, are the substrates of the HFOs detected by clinical depth electrodes. This feature was prominent in three patients but rarely seen in only one patient recorded outside epileptogenic cortex. Additionally, they found that HFOs were commonly associated with widespread interictal epileptiform discharges but not with locally generated ‘microdischarges’. These observations raise the possibility that, rather than being initiators of epileptiform activity, fast ripples may be markers of a secondary local response.

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