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Guilleminault C et al. – Respiratory–related evoked potential are significantly reduced in OSA patients during non–rapid eye movement sleep indicating a sleep–related blunted cortical response to inspiratory occlusion. Histologic investigations of palatopharyngeal muscles from OSA patients show evidence of motor neuron lesions and actual damage to the muscles. Currently demonstrated local neurologic impairment and lesions can explain the development of sleep apneas and hypopneas.

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