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Plesec TP et al. – Frozen section (FS) for intraoperative evaluation of central nervous system (CNS) lesions provides the neurosurgeon with a rapid preliminary pathologic diagnosis. Diagnosis of nonneoplastic lesions is particularly challenging in this venue. Nonneoplastic lesions are often more challenging than neoplastic lesions at FS, particularly because they are less commonly sampled for FS and, therefore, less familiar to pathologists.

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