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Dopamine Agonists Diminish Value Sensitivity of the Orbitofrontal Cortex: A Trigger for Pathological Gambling in Parkinson's Disease
Neuropsychopharmacology, 09/24/09
Eimeren TV et al. – The authors propose that DAs prevent pauses in dopamine transmission and thereby impair the negative reinforcing effect of losing. The findings raise the question of whether pathological gambling may in part stem from an impaired capacity of the OFC to guide behavior when facing negative consequences.
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