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Phase II trial of CoQ10 for ALS finds insufficient evidence to justify phase III
Annals of Neurology , 09/18/09
Kaufmann P et al. – CoQ10 at 2,700mg daily for 9 months shows insufficient promise to warrant Phase III testing. Given this outcome, the adaptive Phase II design incorporating a dose selection and a futility test avoided the need for a much larger conventional Phase III trial.
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